Chemical Changes in Blood and Intestinal Juice Produced by the Loss of Intestinal Juice*

The rBle of the loss of gastrointestinal secretions in the pathogenesis of intestinal obstruction has become recognized as one of great importance. The chemical changes produced by the loss of gastric juice have been studied by MacCallum and coworkers (l), Haden and Orr (2), Gamble and Ross (3), Hastings, Murray, and Murray (4), and Dragstedt and Ellis (5). The changes produced by the loss of pancreatic juice have been studied by Elman and McCaughan (6), Gamble and McIver (7), Elman and Hartmann (8), and Dragstedt and coworkers (9). Similar studies on the loss of the secretion of the intestine are lacking. The report of Herrin and Meek (10) that distention of jejunal fistuhe in dogs produced the chemical changes in the blood as well as the symptoms and signs of intestinal obstruction made it seem desirable to study extensively the chemical composition of succus entericus and the effect of its loss on the chemical composition of the blood.